Beilstein J. Org. Chem.2022,18, 479–485, doi:10.3762/bjoc.18.50
, Nakhonsithammarat 80160, Thailand 10.3762/bjoc.18.50 Abstract Two new sesquiterpenes, trichocitrinovirenes A (1) and B (2), and five known compounds including four structurally related sesquiterpenes and one γ-lactone were isolated from the soil-derivedfungus Trichoderma citrinoviride PSU-SPSF346. The structures
. Compound 2 possesses a rare bicyclic sesquiterpene skeleton. The antimicrobial and cytotoxic activities of the isolated compounds were evaluated.
Keywords: antimicrobial activity; cytotoxic activity; γ-lactone; soil-derivedfungus; sesquiterpene; Trichoderma citrinoviride; Introduction
The fungus
concentration of 50 μg/mL.
Conclusion
The investigation of the crude extracts of the soil-derivedfungus T. citrinoviride PSU-SPSF346 resulted in the isolation of seven compounds including two new (1 and 2) and four known sesquiterpenes (3–6), and one known γ-lactone (7). Sesquiterpenes of this type were
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Graphical Abstract
Figure 1:
Structures of compounds 1–7 isolated from Trichoderma citrinoviride PSU-SPSF346.